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中药标准品
|
产品编号 |
英文名称 |
CAS号 |
包装 |
|
Y3735 |
()-Huperzine A |
02518-79-6 |
可根据客户要求订制 |
英文名称：()-Huperzine A
CAS号： 02518-79-6
分析标准品
分子式 C15H18N2O 分子量242.32
基本信息:
溶解性 易溶于氯仿，溶于甲醇、乙醇，微溶于水
存贮条件 储存温度2-8℃
描述
别名 (-)-石杉碱甲;(-)-Selagine
生化机理
Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease.
应用 石杉碱甲不仅通过抑制胆碱酯酶活性，还可以通过影响自由基系统，降低生长抑素、细胞内[Ca2+]、谷氨酸含量，提高钙调蛋白(CaM)和钙调蛋白的信使核糖核酸(CaM mRNA)表达水平等多种药理机制，提高认知功能和学习记忆能力。
存贮条件 储存温度2-8℃
描述
别名 (-)-石杉碱甲;(-)-Selagine
生化机理
Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease.
应用 石杉碱甲不仅通过抑制胆碱酯酶活性，还可以通过影响自由基系统，降低生长抑素、细胞内[Ca2+]、谷氨酸含量，提高钙调蛋白(CaM)和钙调蛋白的信使核糖核酸(CaM mRNA)表达水平等多种药理机制，提高认知功能和学习记忆能力。
